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If we take the area postrema as an example and consider the established role of the area postrema in nausea and emesis, together with what we know about the role of GLP‐1 receptor signalling in nausea and emesis, we could postulate that these receptors in the area postrema signal nausea in response to an unusually large release of GLP‐1 from the gut that signals intestinal discomfort/malaise
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